BDBM50249319 2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenylamino)pyrimidine-5-carboxamide::CHEMBL471901

SMILES NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1

InChI Key InChIKey=FQNFLNSVHWCZML-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50249319   

TargetTyrosine-protein kinase ZAP-70(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 41nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 41nMAssay Description:Inhibition of spleen tyrosine kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 41nMAssay Description:Inhibition of p72 SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 456nMAssay Description:Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50249319(CHEMBL471901 | 2-(2-aminoethylamino)-4-(3-(trifluo...)
Affinity DataIC50: 432nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed