BDBM50249258 CHEMBL475570::N-(2,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2-amine

SMILES Cc1ccc(C)c(Nc2nccc(n2)-c2nccs2)c1

InChI Key InChIKey=WPPTYGSKZRVJSC-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50249258   

TargetTyrosine-protein kinase SYK(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50249258(N-(2,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2...)
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249258(N-(2,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2...)
Affinity DataKi:  153nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50249258(N-(2,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2...)
Affinity DataKi:  1.82E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249258(N-(2,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed