BDBM50249107 15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide::CHEMBL474770

SMILES Cc1cnc(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc32)s1

InChI Key

Data  6 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50249107   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataKi:  4.10nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataKi:  12.7nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataKi:  12.7nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataEC50:  345nMAssay Description:Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataEC50:  609nMAssay Description:Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataEC50:  610nMAssay Description:Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of radioligand from estrogen receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of radioligand from progesterone receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249107(15-methyl-N-(5-methyl-1,3-thiazol-2-yl)tetracyclo[...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of radioligand from androgen receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed