BDBM50248935 CHEMBL4062202::US10981896, Compound 23

SMILES CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3cc(ccc23)C(=O)NCCCN)c2ccccc2)cc1

InChI Key InChIKey=BVOQGWISHQHEIZ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248935   

TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248935(CHEMBL4062202 | US10981896, Compound 23)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248935(CHEMBL4062202 | US10981896, Compound 23)
Affinity DataIC50: 5.00E+3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248935(CHEMBL4062202 | US10981896, Compound 23)
Affinity DataKi: >650nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed