BDBM50248925 CHEMBL4061117::US10981896, Compound 22

SMILES CN(C)CCCNC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=MMOUAXSBHFONTL-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248925   

TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248925(CHEMBL4061117 | US10981896, Compound 22)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248925(CHEMBL4061117 | US10981896, Compound 22)
Affinity DataIC50: 2.70E+3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetMaternal embryonic leucine zipper kinase(Human)
The University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248925(CHEMBL4061117 | US10981896, Compound 22)
Affinity DataKi:  358nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed