BDBM50248715 (E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-dimethoxy-2,3-dihydroinden-1-one::CHEMBL464427

SMILES CCN(CC)Cc1ccc(\C=C2/Cc3cc(OC)c(OC)cc3C2=O)cc1

InChI Key InChIKey=BINZQDMZAMRQON-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50248715   

TargetCarboxylic ester hydrolase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50248715((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibition of BChE in rat serum after 15 mins by modified Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50248715((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Affinity DataIC50: 35nMAssay Description:Inhibition of AChE in rat cortex after 15 mins by modified Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50248715((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Affinity DataIC50: 35nMAssay Description:Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article

TargetAcetylcholinesterase(Human)
Universit�

Curated by ChEMBL
LigandPNGBDBM50248715((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human serum recombinant AChE using acetylthiocholine iodide as a substrate incubated for 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Universit�

Curated by ChEMBL
LigandPNGBDBM50248715((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Affinity DataIC50: 783nMAssay Description:Inhibition of human recombinant MAO-B assessed as reduction in 4-hydroxyquinoline level using kynuramine as a substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Universit�

Curated by ChEMBL
LigandPNGBDBM50248715((E)-2-{4-[(Diethylamino)methyl]benzylidene}-5,6-di...)
Affinity DataKi:  453nMAssay Description:Binding affinity to acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article