BDBM50248604 (3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl)methanone::CHEMBL460545::US9139546, 28

SMILES Oc1cc(cc(O)c1-c1cc(Cl)cc(Cl)c1)C(=O)c1ccccc1

InChI Key InChIKey=CRNLOOZHRPDURJ-UHFFFAOYSA-N

Data  8 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50248604   

TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataEC50:  153nMAssay Description:Inverse agonist activity at CB2 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production measured at 50 mins by ACTOn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataEC50:  155nMAssay Description:Inverse agonist activity at human recombinant cannabinoid CB2 receptor expressed in HEK cells transfected with CNG assessed as increase in cAMP level...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataEC50:  155nMAssay Description:Inverse agonist activity at cannabinoid CB2 receptor in human U2OS cells assessed as induction of beta-arrestin recruitment using CCF4/AM as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  2.94nM ΔG°:  -11.8kcal/moleT: 2°CAssay Description:15.3 ug of membranes (20 ul of 1:20 dilution in incubation buffer) was incubated with 5 ul of drug solution (10E-4M to 10E-12M) and 5ul of 5.4 nM [3H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  2.94nMAssay Description:Binding affinity to human CB2 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
The University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  27nM ΔG°:  -10.5kcal/moleT: 2°CAssay Description:8 ug of membranes (20 ul of 1:8 dilution in incubation buffer) was incubated with 5 ul of drug solution (10E-4M to 10E-12M) and 5ul of 5.4 nM [3H]CP5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetCannabinoid receptor 1(Human)
The University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  27nMAssay Description:Binding affinity to human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]-CP55940 from CB2 receptor (unknown origin) expressed in CHO cell membranes after 90 mins by liquid scintillation counting analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  121nMAssay Description:Displacement of [3H]-CP55940 from human recombinant cannabinoid CB2 receptor expressed in HEK cell membranes incubated for 1.5 hrs by liquid scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
The University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  4.78E+3nMAssay Description:Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) expressed in CHO cell membranes after 90 mins by liquid scintillation counting analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
The University of Tennessee Research Foundation

US Patent
LigandPNGBDBM50248604((3',5'-dichloro-2,6-dihydroxybiphenyl-4-yl)(phenyl...)
Affinity DataKi:  4.78E+3nMAssay Description:Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cell membranes incubated for 1.5 hrs by liquid scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed