BDBM50248570 3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide::CHEMBL460963::US10201527, Compound 17::US10736881, Compound 17::US8551988, 17

SMILES CN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12

InChI Key InChIKey=FOLVOXAEHBGIDM-UHFFFAOYSA-N

Data  9 KI  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50248570   

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 42nMAssay Description:Inhibition of full length recombinant HDAC1 using Fluor de Lys as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 353nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 24nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetHistone H3.1(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataEC50:  1.10E+3nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 353nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 24nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Mei Pharma

US Patent
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 353nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataIC50: 24nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC3 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  15nMAssay Description:Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  16nMAssay Description:Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  16nMAssay Description:Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  21nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  23nMAssay Description:Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  23nMAssay Description:Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
S*Bio

Curated by ChEMBL
LigandPNGBDBM50248570(CHEMBL460963 | US8551988, 17 | 3-(1-(3-(dimethylam...)
Affinity DataKi:  39nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed