BDBM50248566 1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclopropanecarboxamide::CHEMBL465955

SMILES C[C@@H]1CN(CC2(CC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)C(C)(O)C(F)(F)F

InChI Key InChIKey=YJFULAYRAKPBCY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248566   

LigandPNGBDBM50248566(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50248566(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248566(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)
Affinity DataIC50: 25.4nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248566(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed