BDBM50248487 2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(thiazol-2-yl)benzamide::CHEMBL491121

SMILES Cn1cnnc1Sc1ccc(N)c(c1)C(=O)Nc1nccs1

InChI Key InChIKey=SGEAXPZPLDIFIY-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248487   

TargetHexokinase-4(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50248487(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  350nMAssay Description:Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50248487(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  130nMAssay Description:Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucoseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50248487(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  420nMAssay Description:Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHexokinase-4(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50248487(2-amino-5-(4-methyl-4H-1,2,4-triazol-3-ylthio)-N-(...)
Affinity DataEC50:  140nMAssay Description:Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed