BDBM50248209 CHEMBL515717::N-cyclopropyl-N-((1s,4R)-4-hydroxy-4-isopropylcyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide

SMILES CC(C)[C@@]1(O)CC[C@@H](CC1)N(C1CC1)C(=O)c1ccc(cc1)[C@](C)(O)C(F)(F)F

InChI Key InChIKey=FRTCCDLOIBDORK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248209   

LigandPNGBDBM50248209(N-cyclopropyl-N-((1s,4R)-4-hydroxy-4-isopropylcycl...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of FLAG-tagged full length human 11beta-HSD1 expressed in baculovirus-infected Trichoplusia ni Hi5 cells assessed as reduction of [3H]cort...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50248209(N-cyclopropyl-N-((1s,4R)-4-hydroxy-4-isopropylcycl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in absence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50248209(N-cyclopropyl-N-((1s,4R)-4-hydroxy-4-isopropylcycl...)
Affinity DataIC50: 69nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in HEK293 cells in presence of 3% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed