BDBM50247616 2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one::CHEMBL489102

SMILES Fc1c(Cl)cccc1-n1sccc1=O

InChI Key InChIKey=FLVXYAGCEOJNQC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50247616   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50247616(2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one | ...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins in presence of 5 mM GSH by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50247616(2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one | ...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Swiss Institute of Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50247616(2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one | ...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of IDO1 (unknown origin) using L-tryptophan substrate incubated for 60 mins in presence of 0.01% Triton-X by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50247616(2-(3-chloro-2-fluorophenyl)isothiazol-3(2H)-one | ...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of GST-fused recombinant HAT PCAF expressed in Escherichia coli by filter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed