BDBM50247191 (2S,3S)-2-Amino-3-benzyloxy-succinic acid::CHEMBL475341::D,L-threo-beta-benzyloxyaspartate::DL-2-amino-3-(benzyloxy)succinic acid::DL-threo-beta-benzyloxyaspartate

SMILES c1ccc(cc1)CO[C@@H]([C@@H](C(=O)O)N)C(=O)O

InChI Key InChIKey=BYOBCYXURWDEDS-UHFFFAOYSA-N

Data  14 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50247191   

TargetExcitatory amino acid transporter 3(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 8.00E+3nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 7.00E+3nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 4.80E+4nMAssay Description:Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetGlutamate transporter homolog(Pyrococcus horikoshii (strain ATCC 700860 / DSM 12...)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataKd:  100nMAssay Description:Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter D405N mutant in presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of rat EAAT4 transfected in human tsA201 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 3.89E+3nMAssay Description:Inhibition of rat EAAT4 transfected in human tsA201 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 1(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 2(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetExcitatory amino acid transporter 3(Human)
Institute For Bioorganic Research

Curated by ChEMBL
LigandPNGBDBM50247191((2S,3S)-2-Amino-3-benzyloxy-succinic acid | DL-thr...)
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed