BDBM50247151 7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL514795::US9290501, (C)

SMILES CSC[C@H]1CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O

InChI Key InChIKey=DBPWKRQKYPFTJB-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50247151   

TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0196nMAssay Description:Equilibrium binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-inhibitor complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.100nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(Human)
Albert Einstein College of Medicine of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant human PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.340nM ΔG°:  -12.9kcal/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
Go to US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Victoria University of Wellington

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed