BDBM50246493 CHEMBL455448::rac-2-((methylamino)methyl)-1-(o-tolyloxy)-2,3-dihydro-1H-inden-2-ol

SMILES CNCC1(O)Cc2ccccc2C1Oc1ccccc1C

InChI Key InChIKey=YIEXSVBTWQZEGZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50246493   

TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246493(rac-2-((methylamino)methyl)-1-(o-tolyloxy)-2,3-dih...)
Affinity DataIC50: 30nMAssay Description:Inhibition of norepinephrine uptake at human NET transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246493(rac-2-((methylamino)methyl)-1-(o-tolyloxy)-2,3-dih...)
Affinity DataIC50: 700nMAssay Description:Inhibition of serotonin uptake at human SERT transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246493(rac-2-((methylamino)methyl)-1-(o-tolyloxy)-2,3-dih...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of dopamine uptake at human DAT transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246493(rac-2-((methylamino)methyl)-1-(o-tolyloxy)-2,3-dih...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed