BDBM50246492 CHEMBL455447::N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-inden-2-yl)methanamine

SMILES CNC[C@@H]1Cc2ccccc2[C@@H]1Oc1ccccc1C

InChI Key InChIKey=OQRZMLVFIJAOKO-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50246492   

TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 10nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 7nMAssay Description:Inhibition of norepinephrine uptake at human NET transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of dopamine uptake at human DAT transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50246492(N-methyl((1R,2S)-1-(o-tolyloxy)-2,3-dihydro-1H-ind...)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed