BDBM50246470 CHEMBL455455::N-benzyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide

SMILES FC(F)(F)C(=O)c1ccc(s1)C(=O)NCc1ccccc1

InChI Key InChIKey=MAHDYMLFMJRXOZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50246470   

TargetHistone deacetylase 4(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246470(N-benzyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carb...)
Affinity DataIC50: 243nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246470(N-benzyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carb...)
Affinity DataIC50: 370nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246470(N-benzyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carb...)
Affinity DataIC50: 467nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246470(N-benzyl-5-(2,2,2-trifluoroacetyl)thiophene-2-carb...)
Affinity DataIC50: 520nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed