BDBM50246396 2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)-N-methylbenzamide::CHEMBL455428

SMILES CNC(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1F

InChI Key InChIKey=OCUYCOQPRGFQEV-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50246396   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase-like 1 [2-358](Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246396(2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Zap70More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed