BDBM50246284 CHEMBL487057::N4-((1R,2R)-2-Dimethylamino-cyclopentyl)-N2-(2-methyl-1,1-dioxo-2,3-dihydro-1H-1lambda6-benzo[d]isothiazol-5-yl)-5-trifluoromethyl-pyrimidine-2,4-diamine

SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nc(Nc2ccc3c(CN(C)S3(=O)=O)c2)ncc1C(F)(F)F

InChI Key InChIKey=VDHXKVFKJRJHDS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246284   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246284(N4-((1R,2R)-2-Dimethylamino-cyclopentyl)-N2-(2-met...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246284(N4-((1R,2R)-2-Dimethylamino-cyclopentyl)-N2-(2-met...)
Affinity DataIC50: 25nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed