BDBM50246283 7-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2,3,4,5-tetrahydrobenzo[c]azepin-1-one::CHEMBL518905

SMILES CN(C)[C@@H]1CCC[C@H]1Nc1nc(Nc2ccc3c(CCCNC3=O)c2)ncc1C(F)(F)F

InChI Key InChIKey=HZHMSBKFDZWRLC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246283   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246283(7-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50: 880nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246283(7-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50: 143nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed