BDBM50246189 5-(4-(2-(pyrrolidin-1-ylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-one::CHEMBL529889

SMILES FC(F)(F)c1cnc(Nc2ccc3NC(=O)Cc3c2)nc1NCc1ccccc1S(=O)(=O)N1CCCC1

InChI Key InChIKey=CKRPEFXFIJADJE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50246189   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246189(5-(4-(2-(pyrrolidin-1-ylsulfonyl)benzylamino)-5-(t...)
Affinity DataIC50: 170nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246189(5-(4-(2-(pyrrolidin-1-ylsulfonyl)benzylamino)-5-(t...)
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed