BDBM50246187 5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)indolin-2-one::CHEMBL487246::US10266549, Example 33::US10774092, Example 33

SMILES CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)c1

InChI Key InChIKey=SJMCNVUMRNUOKS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50246187   

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged FAK assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of GST-tagged pyk2 assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 1.10E+3nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Salk Institute

US Patent
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 1.10E+3nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 4nMAssay Description:Inhibition of FAK (unknown origin) (410 to 689 residues) assessed as reduction in poly(Glu-Tyr) phosphorylation using poly (Glu,Tyr) as substrate by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246187(5-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluorom...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of pyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed