BDBM50246034 2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1,2,4-oxadiazol-5-yl}thiophen-2-yl)ethanone::2,2,2-trifluoro-1-(5-(3-(propylsulfonylmethyl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone::CHEMBL471173

SMILES CCCS(=O)(=O)Cc1noc(n1)-c1ccc(s1)C(=O)C(F)(F)F

InChI Key InChIKey=ANGRBZMMPDQGNC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50246034   

TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 500nMAssay Description:Inhibition of HDAC6 in human HCT116 cells assessed as inhibition of alpha-tubulin deacetylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 240nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50: 240nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed