BDBM50245655 CHEMBL4091726

SMILES Fc1cncc(CN2CCc3c(C2)sc2ccc(F)cc32)c1

InChI Key InChIKey=HKISMKOJLMSNFC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50245655   

TargetCytochrome P450 3A4(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50245655(CHEMBL4091726)
Affinity DataIC50: 9.03E+3nMAssay Description:Inhibition of human hepatic CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50245655(CHEMBL4091726)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human CYP17 expressed in human A549 cell membranes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rat)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50245655(CHEMBL4091726)
Affinity DataIC50: 57nMAssay Description:Inhibition of CYP17 in Sprague-Dawley rat testes microsomes using 17-alpha hydroxyprogesterone as substrate and NADPH as cofactor pretreated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed