BDBM50245420 CHEMBL462168::N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)-3-(trifluoromethyl)benzamide

SMILES COc1cc2nccc(Oc3ccc4c(NC(=O)c5cccc(c5)C(F)(F)F)nn(C)c4c3)c2cc1OC

InChI Key InChIKey=VCBGNDQGKNIBBK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50245420   

TargetAurora kinase B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 45nMAssay Description:Inhibition of aurora 1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 121nMAssay Description:Inhibition of Tie 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 764nMAssay Description:Inhibition of aurora 2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of PI3KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of cMETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 2.50E+7nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50: 2.50E+7nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed