BDBM50244510 7-(2,2-dimethylpropyl)-6-[(5-methoxy-2-oxospiro[indole-3,4'-piperidin]-1(2H)-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile::CHEMBL452826

SMILES COc1ccc2N(Cc3cc4cnc(nc4n3CC(C)(C)C)C#N)C(=O)C3(CCNCC3)c2c1

InChI Key InChIKey=KNNCFAJHGHOEJI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50244510   

TargetProcathepsin L(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50244510(7-(2,2-dimethylpropyl)-6-[(5-methoxy-2-oxospiro[in...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50244510(7-(2,2-dimethylpropyl)-6-[(5-methoxy-2-oxospiro[in...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50244510(7-(2,2-dimethylpropyl)-6-[(5-methoxy-2-oxospiro[in...)
Affinity DataIC50: 44nMAssay Description:Inhibition of rat recombinant cathepsin K expressed in Sf21 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed