BDBM50244481 (E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxo-tetrahydrofuran-2-yl)methyl 4-methoxybenzoate::CHEMBL488674

SMILES COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1

InChI Key InChIKey=HTALWVZQUMMIDH-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50244481   

TargetRas guanyl-releasing protein 3(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244481((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]PDBu from RasGRP3 expressed in cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRas guanyl-releasing protein 3(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244481((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244481((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  212nMAssay Description:Displacement of [3H]PDBu from human recombinant PKCalpha expressed in Escherichia coli BL21-21-Gold (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C epsilon type(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50244481((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  380nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCepsilon expressed in baculovirus expression system after 5 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50244481((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...)
Affinity DataKi:  446nMAssay Description:Displacement of [3H]PDBu from full length recombinant human PKCalpha expressed in baculovirus expression system after 5 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed