BDBM50244337 CHEMBL511964::trans-4-(((4-tert-butylcyclohexyl)(5,6-dichloro-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide

SMILES Cn1c(nc2cc(Cl)c(Cl)cc12)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C

InChI Key InChIKey=FFMXJAAJTIMRRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244337   

TargetPro-glucagon(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244337(trans-4-(((4-tert-butylcyclohexyl)(5,6-dichloro-1-...)
Affinity DataIC50: 3.70E+3nMAssay Description:Binding affinity against human GLP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244337(trans-4-(((4-tert-butylcyclohexyl)(5,6-dichloro-1-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity against human GIPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244337(trans-4-(((4-tert-butylcyclohexyl)(5,6-dichloro-1-...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244337(trans-4-(((4-tert-butylcyclohexyl)(5,6-dichloro-1-...)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed