BDBM50244237 CHEMBL448921::trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylmethoxy)-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide

SMILES Cn1c(nc2cc(OCC3CCCC3)ccc12)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C

InChI Key InChIKey=KJIBSXNERLKBDV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50244237   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244237(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylm...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244237(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylm...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against human GIPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244237(trans-4-(((4-tert-butylcyclohexyl)(5-(cyclopentylm...)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed