BDBM50244112 CHEMBL4060484::US10533010, Example I-181::US11208415, Example I-181

SMILES Cc1nn(C)c(C)c1-c1c(Cl)ccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)Nc1cncc(c1)C(O)=O

InChI Key InChIKey=UJBDBUQHMJYLGN-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50244112   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi: <7nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi: <7nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi:  17nMAssay Description:Inhibition of FITC-Bak-BH3/FITC-Bim-BH3 binding to MCL1 (172 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi:  139nMAssay Description:Inhibition of FITC-Bak-BH3/FITC-Bim-BH3 binding to MCL1 (172 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi:  3.20E+3nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi:  3.20E+3nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi:  6.15E+4nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Vanderbilt University

US Patent
LigandPNGBDBM50244112(CHEMBL4060484 | US10533010, Example I-181 | US1120...)
Affinity DataKi:  6.15E+4nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
Go to US Patent