BDBM50243805 (S)-3,5-Dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)-4-fluoro-piperidin-4-ylmethyl]-benzamide::(S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide::CHEMBL488817

SMILES CC1(C[C@H](CCO1)CN2CCC(CC2)(CNC(=O)c3cc(cc(c3)Cl)Cl)F)C

InChI Key InChIKey=DKNDOKIVCXTFHJ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243805   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243805((S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2...)
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at human ERG by voltage-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243805((S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2...)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of sodium channel Nav1.5 by voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243805((S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2...)
Affinity DataIC50: 82nMAssay Description:Inhibition of T-type calcium channel alpha1I (unknown origin) by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50243805((S)-3,5-dichloro-N-((1-((2,2-dimethyl-tetrahydro-2...)
Affinity DataIC50: 3.79E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed