BDBM50243463 CHEMBL4100363

SMILES CC[C@]1(CC(=CNC1=O)c2ccc(s2)S(=O)(=O)Nc3cc4c(cc3F)C=CNC4=O)C

InChI Key InChIKey=SNANFQWFSNYTEC-UHFFFAOYSA-N

Data  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50243463   

LigandPNGBDBM50243463(CHEMBL4100363)
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50243463(CHEMBL4100363)
Affinity DataEC50:  4nMAssay Description:Inhibition of AICARFT in human NCI-H460 cells assessed as increase in ZMP levels using low folate media after 16 hrs by LC-MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)