BDBM50243394 (+)-(S)-7,9-difluoro-2,2,4-trimethyl-5-((S)-3-methylcyclohex-2-enyl)-2,5-dihydro-1H-chromeno[3,4-f]quinoline::(-)-(S)-7,9-difluoro-2,2,4-trimethyl-5-((S)-3-methylcyclohex-2-enyl)-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL453579::rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-yl)-2,2,4-trimethyl 2,5-dihydro-(1H)6-oxa-1-aza-chrysen

SMILES CC1=C[C@H](CCC1)[C@@H]1Oc2c(F)cc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=NNEGFNICKYKFDF-UHFFFAOYSA-N

Data  3 KI  2 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50243394   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataEC50:  50.8nMAssay Description:Agonist activity at human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataEC50:  50.8nMAssay Description:Agonist activity at human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataEC50:  0.5nMAssay Description:Agonist activity at human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human progesterone receptor in human T47D cells assessed as alkaline phosphatase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human progesterone receptor in human T47D cells assessed as alkaline phosphatase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at human androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataIC50: 1.35E+3nMAssay Description:Antagonist activity at human mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity at human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity at human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50243394(rac, syn-7,9-difluoro-5-(3-methylcyclohex-2-en-1-y...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity at human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed