BDBM50243247 CHEMBL4092544

SMILES OCc1cccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3cccnc3n2)c1

InChI Key InChIKey=MXOKNKPVSNPWNS-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50243247   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Temple University

Curated by ChEMBL

LigandBDBM50243247(CHEMBL4092544)Copy SMILESCopy InChI

Affinity DataIC50: 7.80nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2019
Entry Details Article
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TargetSerine/threonine-protein kinase mTOR(Human)
Temple University

Curated by ChEMBL

LigandBDBM50243247(CHEMBL4092544)Copy SMILESCopy InChI

Affinity DataIC50: 83nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL