BDBM50243231 CHEMBL4072084

SMILES O=C(Nc1ccc(cc1)-c1nc(N2CCOCC2)c2ncccc2n1)Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1

InChI Key InChIKey=UBNALVFYIVTRNC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50243231   

TargetSerine/threonine-protein kinase mTOR(Human)
Temple University

Curated by ChEMBL

LigandBDBM50243231(CHEMBL4072084)Copy SMILESCopy InChI

Affinity DataIC50: 26nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2019
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Temple University

Curated by ChEMBL

LigandBDBM50243231(CHEMBL4072084)Copy SMILESCopy InChI

Affinity DataIC50: 50nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
10/17/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL