BDBM50243165 5-(2-p-tolylethynyl)pyrimidine::5-(p-tolylethynyl)pyrimidine::CHEMBL488234

SMILES Cc1ccc(cc1)C#Cc1cncnc1

InChI Key InChIKey=ZOMOIRLSPVPXOT-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50243165   

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243165(5-(2-p-tolylethynyl)pyrimidine | 5-(p-tolylethynyl...)
Affinity DataEC50:  3.30E+3nMAssay Description:Activity at rat mGluR5 expressed in HEK293A cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243165(5-(2-p-tolylethynyl)pyrimidine | 5-(p-tolylethynyl...)
Affinity DataEC50:  3.30E+3nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243165(5-(2-p-tolylethynyl)pyrimidine | 5-(p-tolylethynyl...)
Affinity DataEC50:  3.30E+3nMAssay Description:Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50243165(5-(2-p-tolylethynyl)pyrimidine | 5-(p-tolylethynyl...)
Affinity DataEC50:  3.30E+3nMAssay Description:Positive allosteric modulation activity at mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed