BDBM50243143 CHEMBL3109142

SMILES OCc1ccc(NC(=O)Nc2ccc(cc2)-c2nc(N3CCOCC3)c3ncccc3n2)cc1

InChI Key InChIKey=NUVCPSZAUMDZDL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50243143   

TargetSerine/threonine-protein kinase mTOR(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50: 5nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50: 58nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTOR (unknown origin) after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50: 26nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50243143(CHEMBL3109142)
Affinity DataIC50: 58nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed