BDBM50242927 (-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol Dihydrocholoride::CHEMBL469668

SMILES CN1CCN(C[C@H](c2cccc(OC(F)(F)F)c2)C2(O)CCCCC2)CC1

InChI Key InChIKey=AKRIZMRTOCYSRB-UHFFFAOYSA-N

Data  1 KI  7 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50242927   

TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 82nMAssay Description:Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT1B receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT1B receptor by competition radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT1D receptor by competition radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT2A receptor by competition radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT2B receptor by competition radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT6 receptor by competition radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT7 receptor by competition radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT1D receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT2A receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT2B receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT6 receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at 5HT7 receptor assessed as calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed