BDBM50242402 4-Hydroxynonenal::4-hydroxy-2-nonenal::CHEMBL454280

SMILES CCCCC[C@H](C=CC=O)O

InChI Key InChIKey=JVJFIQYAHPMBBX-UHFFFAOYSA-N

Data  2 IC50  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50242402   

LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at rat TRPA1 channel expressed in tetracycline induced HEK293 cells assessed as increase in intracellular calciumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataEC50:  7.70E+4nMAssay Description:Activation of TRPA1 channel in rat dorsal root ganglion neurons assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataEC50:  2.70E+4nMAssay Description:Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataEC50:  1.99E+4nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlyceraldehyde-3-phosphate dehydrogenase(Human)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GAPDH (unknown origin) measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Flinders University

Curated by ChEMBL
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal His6-tagged human DDAH1 expressed in Escherichia coli measured after 18 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed