BDBM50242248 CHEMBL461060::beta-amyrenone::beta-amyrinone::olean-12-en-3-one

SMILES CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1

InChI Key InChIKey=LIIFBMGUDSHTOU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50242248   

TargetNitric oxide synthase, inducible(Mouse)
National Cheng Kung University

Curated by ChEMBL
LigandPNGBDBM50242248(olean-12-en-3-one | beta-amyrenone | beta-amyrinon...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50242248(olean-12-en-3-one | beta-amyrenone | beta-amyrinon...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of aldose reductase in rat lens homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50242248(olean-12-en-3-one | beta-amyrenone | beta-amyrinon...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Osaka University

Curated by ChEMBL
LigandPNGBDBM50242248(olean-12-en-3-one | beta-amyrenone | beta-amyrinon...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCocaine esterase(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50242248(olean-12-en-3-one | beta-amyrenone | beta-amyrinon...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CES2A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50242248(olean-12-en-3-one | beta-amyrenone | beta-amyrinon...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CES1A1 in human liver microsomes using D-luciferin methyl ester as substrate preincubated for 10 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed