BDBM50242050 CHEMBL4085511

SMILES COc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(cc1)C(=O)Nc1ccccc1N

InChI Key InChIKey=GYCHHPOEULHRMT-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50242050   

TargetHistone deacetylase 1(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 65nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 157nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 135nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 169nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 939nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 184nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition measured after 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 21nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 138nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 100nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 157nMAssay Description:Inhibition of HDAC2 (unknown origin) using Boc-Lys (acetyl)-AMC as substrate incubated for 10 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 50nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 35nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 348nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 252nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 121nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 433nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 co-expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Medical University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 21nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys (acetyl)-AMC as substrate incubated for 10 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50242050(CHEMBL4085511)
Affinity DataIC50: 138nMAssay Description:Inhibition of HDAC3 (unknown origin) using Boc-Lys (acetyl)-AMC as substrate incubated for 10 mins followed by substrate addition measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details Article
PubMed