BDBM50241748 CHEMBL518059::dihydro-beta-erythroidine

SMILES CO[C@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@@]23C1

InChI Key InChIKey=ALSKYCOJJPXPFS-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50241748   

TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50241748(dihydro-beta-erythroidine | CHEMBL518059)
Affinity DataIC50: 1.00E+5nMAssay Description:Activity at rat alpha3beta4 nicotinic receptor expressed in KXalpha-3-beta-4R2 cells assessed as nicotine-induced 86Rb+ effluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50241748(dihydro-beta-erythroidine | CHEMBL518059)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at (alpha4beta2)2alpha5 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced curre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Chile

Curated by ChEMBL
LigandPNGBDBM50241748(dihydro-beta-erythroidine | CHEMBL518059)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at (alpha4beta2)2alpha4 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced curre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Chile

Curated by ChEMBL
LigandPNGBDBM50241748(dihydro-beta-erythroidine | CHEMBL518059)
Affinity DataIC50: 410nMAssay Description:Antagonist activity at (alpha4beta2)2beta2 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced curren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
University of Chile

Curated by ChEMBL
LigandPNGBDBM50241748(dihydro-beta-erythroidine | CHEMBL518059)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]cytisine from alpha4/beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50241748(dihydro-beta-erythroidine | CHEMBL518059)
Affinity DataKi:  1.05E+4nMAssay Description:Displacement of [3H]cytisine from alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed