BDBM50240877 CHEMBL158897::Quinolyl derivatives::cyclohexanone O-6-((cyclohexylideneaminooxy)carbonylamino)hexylcarbamoyl oxime

SMILES O=[#6](-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-1

InChI Key InChIKey=IIDAYHCOYCVPTJ-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50240877   

TargetLIP1, secretory lipase (Family 3)(Dandruff-associated fungus)
South China University of Technology

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 7.53E+4nMAssay Description:Inhibition of Malassezia globosa CBS 7966 LIP1 using pNPA substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2016
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human DAGLalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of recombinant FAAH transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetPhosphatidylserine lipase ABHD16A(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of recombinant BAT5 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetLysophosphatidylserine lipase ABHD12(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant ABHD12 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetNeutral cholesterol ester hydrolase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant KIAA1363 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetDiacylglycerol lipase-beta(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DAGLbeta overexpressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50240877(Quinolyl derivatives | cyclohexanone O-6-((cyclohe...)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed