BDBM50240819 CHEMBL4084119

SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O

InChI Key InChIKey=YSDQQAXHVYUZIW-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 Kd  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50240819   

TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  0.0670nMAssay Description:Agonist activity at human GLP1 receptor expressed in HEK293 cells harboring mCerulean and mCitrine fused Epac protein assessed as increase in cAMP le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2019
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  0.0660nMAssay Description:Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as induction of cAMP levels after 20 mins by time-resolved fluorescence an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataKd:  6.27E+3nMAssay Description:Binding affinity to GLP-1 receptor (unknown origin) assessed as equlibrium constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in absence of BETP by plate reader met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  1.80nMAssay Description:Agonist activity at FAP-tagged human GLP-1R expressed in HEK293 cells assessed as receptor internalizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  0.950nMAssay Description:Agonist activity at GLP-1R (unknown origin) expressed in candidate selection CHO cells assessed as cAMP accumulation incubated for 30 mins by plate r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cells assessed as induction of beta-arrestin 2 recruitment incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  34nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-1 cell assessed as induction of beta-arrestin 1 recruitment incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Fuzhou University

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of human GST-tagged MUS81-ECE1 expressed in Escherichia coli BL21(DE3)Rosetta2 cells incubated for 15 mins by FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]GLP-1 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50240819(CHEMBL4084119)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed