BDBM50240282 CHEMBL4090731

SMILES CC1(C)CN2CCC[C@@]2(CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)C1

InChI Key InChIKey=XBIMZDZZPNFVOV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50240282   

TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 27nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after hyperpolarization to -115 mV for 8s followed by 20ms p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Department of Discovery Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed