BDBM50239951 CHEMBL4100008

SMILES OCCNS(=O)(=O)c1ccc(cc1)-c1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1

InChI Key InChIKey=JRZSRMXZQHPNOV-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50239951   

TargetMatrix metalloproteinase-14(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP14 using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant human MMP1 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of MMP8 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MMP9 (unknown origin) using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human MMP2 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 12nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human MMP13 using APMA and fTHP-15(FAM) as substrate preincubated for 30 mins followed by substrate addition by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of MMP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCollagenase 3(Human)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50239951(CHEMBL4100008)
Affinity DataKi:  9.20nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using varying levels of fTHP-15 as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed