BDBM50239943 CHEMBL4099869::US9872852, Example 8

SMILES Cc1c(COc2ccc(CN3CCCCC3C(O)=O)cc2Br)cccc1-c1ccccc1

InChI Key InChIKey=QRXBPPWUGITQLE-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50239943   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of PD1-Tag2/PD-L1-Tag1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Henan University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr by spectrophometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Acharya & Bm Reddy College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interaction by luminescence proximity homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Acharya & Bm Reddy College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Acharya & Bm Reddy College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Acharya & Bm Reddy College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Acharya & Bm Reddy College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of Ig-tagged PD-1 (unknown origin)/His-tagged PD-L1 (unknown origin) protein-protein interaction preincubated with PD-L1 for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of human PD-1/PDL1 protein-protein interaction measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) by HTRF binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Henan University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 780nMAssay Description:Inhibition of FC-tagged PD1/His-tagged PD-L1 (unknown origin) protein-proteiinteraction incubated for 3 hrs by coimmunoprecipitation-based Western bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of human PD-1/PDL1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of human C-terminal Ig-Fc-tagged PD1 (Leu25 to Gln167 residues) expressed in HEK293 cells/human C-terminal epitope-His-tagged PDL1 (Phe19 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of Ig-tagged human PD1/His-tagged human PDL1 interaction incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of PD1/PDL1 interaction (unknown origin) after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Henan University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Henan University

Curated by ChEMBL
LigandPNGBDBM50239943(US9872852, Example 8 | CHEMBL4099869)
Affinity DataIC50: 146nMAssay Description:All binding studies were performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (withv) bovine serum albumin and 0.05% (v/v) Twe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
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