BDBM50239718 CHEMBL4064666::US10214537, Example 639

SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C#N)-c1cc(c2c(N)ncnn12)C(F)(F)F

InChI Key InChIKey=ZDXIDBRGTYDHBQ-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50239718   

TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of PI3Kdelta in mouse whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 35nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-CD3/anti-CD28-mediated IFNgamma production preincubated for 1 hr followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:PS as substrate after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 35nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgD-mediated B-cell activation by measuring decrease in CD19+ cells expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 700nMAssay Description:Inhibition of CLK4 (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 370nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 66nMAssay Description:Inhibition of MNK1 (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 41nMAssay Description:Inhibition of PI3Kgamma (unknown origin) after 60 mins using fluorescein-labeled kinase tracer by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2:PS as substrate after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 170nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2:PS as substrate after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50239718(US10214537, Example 639 | CHEMBL4064666)
Affinity DataIC50: 2nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent