BDBM50239459 CHEMBL4074929

SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12

InChI Key InChIKey=VLFFBQAZZDJCHK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50239459   

TargetAnoctamin-1(Human)
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50: 83nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50: 30nMAssay Description:Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetAnoctamin-2(Human)
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50: 400nMAssay Description:Inhibition of human TMEM16B expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetAnoctamin-1(Mouse)
Korea University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50: 50nMAssay Description:Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inhibition of ATP-induced channel current amplitude at membrane pot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50: 30nMAssay Description:Inhibition of ANO1 channel (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
San Francisco State University

Curated by ChEMBL
LigandPNGBDBM50239459(CHEMBL4074929)
Affinity DataIC50: 30nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed