BDBM50239399 CHEMBL4069027

SMILES C[C@@H](c1nc2cccc(C)c2c(=O)n1-c1ccccc1C)n1cnc2c(N)ncnc12

InChI Key InChIKey=DGRRTXHMRRNKFX-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50239399   

LigandPNGBDBM50239399(CHEMBL4069027)
Affinity DataIC50: 6.31nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50239399(CHEMBL4069027)
Affinity DataIC50: 1.26nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50239399(CHEMBL4069027)
Affinity DataKi:  1.58nMAssay Description:Inhibition of human recombinant full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50239399(CHEMBL4069027)
Affinity DataKi:  3.16nMAssay Description:Inhibition of human recombinant full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed